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Title:
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Assistant Investigator, Shriners Hospitals for Children
Assistant Professor, Department of Pathology & Laboratory Medicine, UCD SOM
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Office Address:
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2425 Stockton Blvd, Room 671
Sacramento, CA 95817
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Office Phone:
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(916) 453-2189
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E-Mail Address:
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kzarbalis (at) ucdavis.edu
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Education:
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Postdoctoral Training, Developmental Neurobiology, UCSF
PhD, Molecular Biology and Genetics, Technical University Munich, Germany
MS, Biology, Technical University Munich, Germany
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Research Papers:
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Click Here for Research Paper Links
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Research Interests:
The analysis of genetic and molecular mechanisms regulating neural and craniofacial development.
Current Research:
Among the most important tools in the analysis of developmental processes like growth, patterning, and differentiation has been the study of mutants, in which aspects of development are adversely affected. A powerful approach to obtain developmental mutants is forward genetic screens. We carried out such a screen in the mouse aimed at the identification of mutants displaying forebrain defects. Several mutant lines with defects during forebrain development were recovered and the mutated genes identified. Neuronal defects in the lines obtained affect overall cortical morphology, neuronal migration, cortical lamination, and thalamocortical connectivity. Other lines show craniofacial defects of great interest affecting orofacial and skull morphology. Current projects involve the molecular, cellular, and morphological analysis of these mutants.
Noteworthy Publications:
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Extracellular Engrailed participates in the topographic guidance of retinal axons in vivo. Neuron 64 (2009) 355-366.
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Wizenmann A., Brunet I., Lam J., Sonnier L., Beurdeley M., Zarbalis K., Weisenhorn-Vogt D., Weinl C., Dwivedy A., Joliot A., Holt C., Wurst W., Prochiantz A.
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2009
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Retinoic acid from the meninges regulates cortical neuron generation. Cell 139 (2009) 597-609.
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Siegenthaler J. A., Ashique A. M.*, Zarbalis K.*, Patterson K. P., Hecht J. H., Kane M. A., Folias A. E., Choe Y., May S. R., Kume T., Napoli J. L., Peterson A. S., Pleasure S. J.
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2009
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Cortical dysplasia and skull defects in mice with a novel Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. PNAS 104 (2007) 14002–14007.
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Zarbalis K.*, Siegenthaler J. A.*, Choe Y., May S. R., Peterson A. S., Pleasure S. J.
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2007
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EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 129 (2007) 359-370.
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Konstantinova I., Nikolova G., Ohara-Imaizumi M., Meda P., Kucera T., Zarbalis K., Wurst W., Nagamatsu S., Lammert E.
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2007
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The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene 26 (2007) 2272-2282 [with correction in 26 (2007) 5692].
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Dow L. E., Kauffman J. S., Caddy J., Zarbalis K., Peterson A. S., Jane S. M., Russell S. M., Humbert P. O.
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2007
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Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol. 287 (2005) 378-89.
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May S. R., Ashique A. M., Karlenc M., Wang B., Shen Y., Zarbalis K., Reiter J., Ericson J., Peterson A. S.
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2005
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A focused and efficient genetic screening strategy in the mouse: Identification of mutations that disrupt cortical development. PLoS Biology 2 (2004) 1177-1187.
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Zarbalis, K.*, May, R. S.*, Shen, Y., Ekker, M., Rubenstein, J. L. R., Peterson, A.
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2004
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Multiple roles of ephrins during the formation of thalamocortical projections: Maps and more. J. Neurobiol. 59 (2004) 82-94.
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Bolz, J., Mühlfriedel, S., Güllmar, A., Peuckert, C., Zarbalis, K., Wurst, W., Masaaki, T., Levitt, P.
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2004
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Miswiring of limbic thalamocortical projections in the absence of ephrin-A5. J. Neurosci. 22 (2002) 9352-9357.
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Uziel D., Mühlfriedel S., Zarbalis K., Wurst W., Levitt P., Bolz J.
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2002
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A role for the EphA family in the topographic targeting of vomeronasal axons. Development 128 (2001) 895-906.
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Knöll B.*, Zarbalis K.*, Wurst W., Drescher U.
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2001
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Expression domains of murine ephrin-A5 in the pituitary and hypothalamus. Mech. Dev. 93 (2000) 165-168.
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Zarbalis K. and Wurst W.
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2000
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* equal contribution
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